Cardiovascular Health

Key Indications:  Spermidine may have a preventative effect on age-related cardiovascular diseases. Spermidine may improve cellular respiration by increasing the mitochondrial content of heart cells. Myocardial muscle cells, the so-called cardiomyocytes, which are responsible for the contraction of the heart, take up spermidine via a specific cellular transporter, potentially triggering autophagy. Increased NO availability in these cells may lead to reduced systemic inflammation.

Human Studies

Food Polyamine and Cardiovascular Disease - An Epidemiological Study. Learn More >

Animal Studies

Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy. Learn More >

Cardioprotection and lifespan extension by the natural polyamine spermidine. Learn More >

Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes. Learn More >

Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy. Learn More >