• Immune System Support
  • Neurodegeneration and Brain Health
  • Cardiovascular Health
  • Bone and Cartilage Health
  • Muscle Function
  • Aging and Longevity
  • Diabetes and Obesity
  • Hair Growth
  • Liver Health
  • Ongoing and Upcoming Study Topics

Key Indications:  Supplementation of spermidine may reduce the inflammatory cytokines and may lead to an increased production of memory cells. Autophagy may play a major role in immune defense and may support the disposal of pathogenic microorganisms. Autophagy may help mediate immunological memory in older age.

Human Studies

Key Indications:  Supplementation of spermidine may reduce the inflammatory cytokines and may lead to an increased production of memory cells. Autophagy may play a major role in immune defense and may support the disposal of pathogenic microorganisms. Autophagy may help mediate immunological memory in older age.

Spermidine, a natural polyamine, suppresses LFA-1 expression on human lymphocyte. Learn More >

Autophagy Defends Cells Against Invading Group A Streptococcus.

Animal Studies

Cytoplasmic bacteria can be targets for autophagy. Learn More >

Selective Modulation of Autophagy, Innate Immunity, and Adaptive Immunity by Small Molecules.

MHC class II antigen loading compartments continuously receive input from autophagosomes. Learn More >

Key Indications: Spermidine can trigger the activation of autophagy which may remove harmful toxic proteins causing diseases such as Parkinson's, Alzheimers, or ALS. This effect was discovered in mice as well as human studies.

Human Studies

Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline. Learn More >

The effect of spermidine on memory performance with older adults at risk for dementia: A randomized controlled trial. Learn More >

Animal Studies

Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43.

Learn More >

Influence of microRNA deregulation on chaperone-mediated autophagy and a-synuclein pathology in Parkinson's disease. Learn More >

Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage.

Key Indications:  Spermidine may have a preventative effect on age-related cardiovascular diseases. Spermidine may improve cellular respiration by increasing the mitochondrial content of heart cells. Myocardial muscle cells, the so-called cardiomyocytes, which are responsible for the contraction of the heart, take up spermidine via a specific cellular transporter, potentially triggering autophagy. Increased NO availability in these cells may lead to reduced systemic inflammation.

Human Studies

Food Polyamine and Cardiovascular Disease - An Epidemiological Study. Learn More >

Animal Studies

Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy. Learn More >

Cardioprotection and lifespan extension by the natural polyamine spermidine. Learn More >

Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes. Learn More >

Polyamines and microbiota in bicuspid and tricuspid aortic valve aortopathy.

Key Indications:  Spermidine may enhance the production of stem cells and shows positive effects on bone density. Spermidine is a natural polyamine which may help prevent bone loss through a preferred disruption of osteoclastic activity on ovariectomized mice.

Animal Studies

Rapamycin and other longevity-promoting compounds enhance the generation of mouse induced pluripotent stem cells. Learn More > 

The Natural Polyamines of Spermidine and Spermine Prevent Bone Loss through Preferential Disruption of Osteoclastic Activation in Ovariectomized Mice. Learn More >

Key Indications:  Spermidine-induced autophagy may reduce age-dependent muscular atrophy.

Animal Studies

Spermidine coupled with exercise rescues skeletal muscle atrophy from D-gal-induced aging rats through enhanced autophagy and reduced apoptosis via AMPK-FOXO3a signal pathway. Learn More > 

Key Indications:  Spermidine and autophagy levels decrease with age in the human organism. Spermidine supplementation may replenish the spermidine pool, induce autophagy in the cells, and prolong life in mice. A long-term epidemiological study demonstrated that higher consumption of spermidine-rich foods correlated with reduced mortality and a 5-year increase in life expectancy.

Human Studies

The importance of dietary polyamines in cell regeneration and growth.

Higher spermidine intake is linked to lower mortality: a prospective population-based study. Learn More >

Animal Studies

Spermidine: a physiological autophagy inducer acting as an anti-aging vitamin in humans? Learn More >

Induction of autophagy by spermidine promotes longevity.

Key Indications:  Polyamines such as spermidine may carry the potential to reduce white adipose tissue and to stimulate the oxidation of fat in the body. Spermidine-induced autophagy may protect wild type mice from the harmful effects of a high-fat diet.

Animal Studies

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Learn More >

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Learn More >

Exogenous administration of spermidine improves glucose utilization and decreases bodyweight in mice. Learn More >

Autophagy Counteracts Weight Gain, Lipotoxicity and Pancreatic B-Cell Death upon Hypercaloric pro-Diabetic Regimens. Learn More >

Key Indications:  Spermidine may enhance hair growth and reduce hair loss by boosting keratin production.

Human Studies

Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. Learn More >

A spermidine-based nutritional supplement prolongs the anagen phase of hair follicles in humans: a randomized, placebo-controlled, double-blind study.

Key Indications:  Spermidine may increase liver protection by strengthening the NRF2 signal transduction via MAP1S-translated non-canonical mechanism. Spermidine may extend the lifespan and help prevent liver fibrosis as well as hepatocellular carcinoma by activating MAP1S-translated autophagy.

Animal Studies

Spermidine Confers Liver Protection by Enhancing NRF2 Signaling Through a MAP1S-Mediated Noncanonical Mechanism. Learn More > 

Spermidine Prolongs Lifespan and Prevents Liver Fibrosis and Hepatocellular Carcinoma by Activating MAP1S-Mediated Autophagy.

Research on spermidine and its positive indications for the human body is just beginning. Stay up to date on the latest studies from researchers across the world. Below are list of ongoing or upcoming study topics that we are aware of or involved in.

Spermidine and Age-Related Diseases (cardiovascular, neurological, and musculoskeletal)

Spermidine and Stroke and Cardiovascular Dementia

Spermidine and Acute Heart Failure

Spermidine and Parkinson's Disease

Spermidine and Hypertension and Blood Pressure

Spermidine and Breast Cancer

Spermidine and Multiple Sclerosis

Spermidine in Cosmetic Indications (wrinkle-reduction)

Spermidine and the Blood-brain Barrier (Alzheimer's)

Spermidine and Heart Failure

Spermidine and Parkinson's Disease and Multiple Sclerosis

Spermidine and Memory Performance in Elderly Persons

Spermidine and Prediabetes