Diabetes And Obesity

Key Indications:  Polyamines such as spermidine may carry the potential to reduce white adipose tissue and to stimulate the oxidation of fat in the body. Spermidine-induced autophagy may protect wild type mice from the harmful effects of a high-fat diet.

Animal Studies

Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Learn More >

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance. Learn More >

Exogenous administration of spermidine improves glucose utilization and decreases bodyweight in mice. Learn More >

Autophagy Counteracts Weight Gain, Lipotoxicity and Pancreatic B-Cell Death upon Hypercaloric pro-Diabetic Regimens. Learn More >